Marijuana is a widely used psychoactive substance in the US, with both medical and recreational legalization on the rise. As more individuals turn to cannabis for various purposes, researchers are delving into the epigenetic effects of its use on the human body. By studying changes in DNA methylation, the biological process by which methyl groups are added to DNA molecules, thereby altering gene expression, scientists are gaining insights into how cannabis can influence health outcomes.
A study of over 1000 adults revealed that cannabis use may cause changes in the human body's epigenome. The researchers found evidence that the drug is associated with DNA methylation, a chemical alteration to the DNA inside human cells. These alterations can have significant implications for overall health and well-being, particularly in the long term. OHSU researchers have also warned of potential impacts on brain development and long-term health related to prenatal cannabis exposure, emphasizing the need for further research in this area.
While cannabis is widely used worldwide, its links to health outcomes are not fully understood. DNA methylation is emerging as a potential mediator to elucidate the complex relationship between cannabis use and health effects. Studies have shown that exposure to THC during pregnancy can lead to changes in DNA methylation in the placenta and the developing fetal brain, raising concerns about the potential long-term consequences for offspring.