Using cannabis may cause changes in the human body's epigenome, a study of over 1,000 adults suggests. The epigenome functions like a set of instructions that tells our genes when to turn on or off, influencing our health and behavior. By studying changes in DNA methylation, the biological process by which methyl groups are added to DNA molecules, thereby altering gene expression, researchers have found a potential link between cannabis use and epigenetic modifications.
Marijuana is a widely used psychoactive substance in the US and medical and recreational legalization has risen over the past decade. With increased access and social acceptance, more people are turning to cannabis for various purposes, from managing pain to simply unwinding after a long day. However, the implications of cannabis use on our genetic makeup are still not fully understood.
Cannabis use, both recent and long-term, has been linked to epigenetic changes in a new study. The researchers found evidence that the drug could alter the expression of certain genes involved in brain function, potentially affecting cognitive processes and mental health. Despite these findings, some individuals may still function normally in their daily lives while being regular cannabis users. “Our data suggests that you can be hard-working, motivated, and a chronic cannabis user at the same time,” the researchers noted.
OHSU researchers warn of potential impacts on brain development and long-term health related to prenatal cannabis exposure. Pregnant individuals are advised to avoid cannabis use due to its potential effects on the developing fetus, including changes in gene expression that may have lasting consequences. Although the effects of cannabis-related epigenetic changes to sperm on fertility or embryonic development are unknown, researchers advocate for caution in cannabis consumption during pregnancy.
A large-scale meta-analysis in Molecular Psychiatry reveals that lifetime cannabis use is associated with DNA methylation changes in certain regions of the genome. These alterations could have implications for various health conditions, including psychiatric disorders and neurological diseases. Understanding the epigenetic effects of cannabis use is crucial for developing personalized treatment strategies and public health policies.
DURHAM, N.C. -- While marijuana use may impact some genes linked to autism in men's sperm, abstaining from cannabis consumption over time can reverse these effects. Researchers emphasize the importance of further investigating the long-term consequences of cannabis use on epigenetic regulation and gene expression. As cannabis continues to be legalized in more regions, it is essential to consider its potential implications on human health and well-being.
