Using cannabis may cause changes in the human body's epigenome, a study of over 1000 adults suggests. By studying changes in DNA methylation, the biological process by which methyl groups are added to DNA molecules, thereby altering gene expression, researchers have uncovered potential links between cannabis use and epigenetic modifications.
Cannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve as a mediator to understand how cannabis use may affect gene regulation and subsequent physiological responses in the body.
Marijuana is a widely used psychoactive substance in the US and medical and recreational legalization has risen over the past decade. Understanding the epigenetic effects of cannabis can provide valuable insights into its potential impact on human health and well-being.
Epigenetics is the study of how environmental factors can alter genetic material, thus influencing the expression of genetic traits. Cannabis, being a potent environmental factor, can potentially induce changes in DNA methylation patterns that may have long-lasting effects on an individual's health.
Over the time course of this study, CB2 mRNA increased in blood lymphocytes in the high concentration THC group but were not accompanied by changes in other genes. This suggests that cannabis may have selective effects on gene expression, particularly those related to the endocannabinoid system.
In a study using pregnant monkeys, researchers found that Cannabis use during pregnancy could potentially affect fetal brain development through epigenetic mechanisms. This highlights the importance of understanding the impact of cannabis on the developing brain and the potential risks associated with prenatal exposure.
DURHAM, N.C. -- While marijuana use may impact some genes linked to autism in men's sperm, abstaining from cannabis consumption over time can potentially reverse these epigenetic changes. This underscores the dynamic nature of epigenetic modifications and their potential for reversal through lifestyle modifications.
The researchers found evidence that the drug is associated with DNA methylation, a chemical alteration to the DNA inside human cells. With further research, scientists hope to elucidate the specific mechanisms by which cannabis induces epigenetic changes and how these alterations may contribute to the observed health outcomes associated with cannabis use.
