The Impact of Cannabis on Epigenetic Changes in the Human Body

Using cannabis may cause changes in the human body's epigenome, a study of over 1,000 adults suggests. The epigenome functions like a set of instructions that determine which genes are turned on or off in different cells at different times. By studying changes in DNA methylation, the biological process by which methyl groups are added to DNA molecules, thereby altering gene expression, researchers have uncovered potential links between cannabis use and epigenetic modifications.

Marijuana is a widely used psychoactive substance in the US, and medical and recreational legalization has risen over the past decade. The researchers found evidence that the drug is associated with DNA methylation, a chemical alteration to the DNA inside human cells. With over 20 million adults in the US reporting past-month marijuana use, understanding the impact of cannabis on epigenetic changes is crucial for public health.

Over the time course of this study, CB2 mRNA increased in blood lymphocytes in the high concentration THC group but were not accompanied by changes in CB1 mRNA compared to the control group. Although the effects of cannabis-related epigenetic changes to sperm on fertility or embryonic development are unknown, researchers advocate for further research to uncover potential risks and benefits.

DURHAM, N.C. -- While marijuana use may impact some genes linked to autism in men's sperm, abstaining from cannabis consumption over time may reverse these effects. OHSU researchers warn of potential impacts on brain development and long-term health related to prenatal cannabis exposure. By studying the epigenetic changes associated with cannabis use, scientists hope to develop targeted interventions to minimize potential harm.

Researchers found that Cannabis use during pregnancy could potentially affect fetal brain development, leading to changes associated with neurobiological and behavioral outcomes. It is essential for pregnant individuals to be informed about the potential risks of cannabis use on their developing child. By understanding the epigenetic mechanisms underlying these effects, researchers can work towards developing strategies to mitigate any negative impacts.